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Rhodium-mediated 18F-oxyfluorination of diazoketones using fluorine-18-containing hypervalent iodine reagent

Abstract

Geminal 18F-oxyfluorination of diazoketones was performed in the presence of rhodium mediators. The reactions were performed using hypervalent iodine-based [18F]fluoro-benziodoxole reagent. By this methodology various α-[18F]fluoro ethers were obtained in high radiochemical yield (up to 98%) and molar activity (216 GBq μmol-1).

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Publication details

The article was received on 04 Sep 2019, accepted on 10 Oct 2019 and first published on 11 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06905D
Chem. Commun., 2019, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Rhodium-mediated 18F-oxyfluorination of diazoketones using fluorine-18-containing hypervalent iodine reagent

    M. A. Cortés González, X. Jiang, P. Nordeman, G. Antoni and K. J. Szabo, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC06905D

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