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Targeting immune checkpoint B7-H3 antibody–chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy

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Abstract

In this study, we constructed bioconjugates of targeting immune checkpoint B7-H3 antibody and chlorin e6 to treat non-small cell lung cancer under the guidance of spectroscopic photoacoustic and fluorescence imaging. The B7-H3–Ce6 conjugates could display effective tumor diagnosis and therapy and provide a novel approach for immunotherapy.

Graphical abstract: Targeting immune checkpoint B7-H3 antibody–chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy

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Publication details

The article was received on 03 Sep 2019, accepted on 15 Oct 2019 and first published on 17 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06839B
Chem. Commun., 2019, Advance Article

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    Targeting immune checkpoint B7-H3 antibody–chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy

    L. Zhu, J. Liu, G. Zhou, H. M. Ng, I. L. Ang, G. Ma, Y. Liu, S. Yang, F. Zhang, K. Miao, T. C. W. Poon, X. Zhang, Z. Yuan, C. Deng and Q. Zhao, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06839B

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