Targeting immune checkpoint B7-H3 antibody–chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy

Lipeng Zhu; Jie Liu; Guangyu Zhou; Hoi Man Ng; Irene L. Ang; Guofang Ma; Yubin Liu; Shuo Yang; Fengjuan Zhang; Kai Miao; Terence C. W. Poon; Xuanjun Zhang; Zhen Yuan; Chu-Xia Deng; Qi Zhao

doi:10.1039/C9CC06839B

Targeting immune checkpoint B7-H3 antibody–chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy†

Lipeng Zhu,‡^a Jie Liu,‡^a Guangyu Zhou,^a Hoi Man Ng,^b Irene L. Ang,^a Guofang Ma,^c Yubin Liu,^a Shuo Yang,^a Fengjuan Zhang,^a Kai Miao,^a Terence C. W. Poon,^a Xuanjun Zhang,

^a Zhen Yuan,

^a Chu-Xia Deng^a and Qi Zhao

*^a

Author affiliations

* Corresponding authors

^a Cancer Centre, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, SAR 999078, China
E-mail: qizhao@um.edu.mo

^b Clinical Laboratory, Kiang Wu Hospital, Macau, SAR 999078, China

^c Geriatric Department, China–Japan Union Hospital of Jilin University, Changchun, Jilin Province, China

Abstract

In this study, we constructed bioconjugates of targeting immune checkpoint B7-H3 antibody and chlorin e6 to treat non-small cell lung cancer under the guidance of spectroscopic photoacoustic and fluorescence imaging. The B7-H3–Ce6 conjugates could display effective tumor diagnosis and therapy and provide a novel approach for immunotherapy.

Chemical Communications

Targeting immune checkpoint B7-H3 antibody–chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy†

Abstract

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