Jump to main content
Jump to site search


Elemental sulfur-promoted one-pot synthesis of 2-(2,2,2-trifluoroethyl)benzoxazoles and their derivatives

Author affiliations

Abstract

A novel and direct strategy has been developed for the synthesis of 2-(2,2,2-trifluoroethyl)benzoxazoles by reaction of o-aminophenols and 2-bromo-3,3,3-trifluoropropene in the presence of elemental sulfur under metal-free conditions. The scope of this methodology was further extended to the synthesis of the trifluoroethylated benzothiazole and benzoimidazole derivatives. A plausible mechanism was proposed on the basis of isolation and characterization of a thioamide intermediate.

Graphical abstract: Elemental sulfur-promoted one-pot synthesis of 2-(2,2,2-trifluoroethyl)benzoxazoles and their derivatives

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Sep 2019, accepted on 08 Oct 2019 and first published on 08 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06822H
Chem. Commun., 2019, Advance Article

  •   Request permissions

    Elemental sulfur-promoted one-pot synthesis of 2-(2,2,2-trifluoroethyl)benzoxazoles and their derivatives

    Z. Li, J. Dong, J. Wang, D. Yang and Z. Weng, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06822H

Search articles by author

Spotlight

Advertisements