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LAMP-generated H+ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA

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Abstract

Herein, an ultrasensitive electrochemical biosensor is proposed for the quantification of the Flu A virus biomarker DNA (fDNA), and is based on loop-mediated isothermal amplification-generated hydrogen ions (LAMP-H+) which induce the formation of the dimer i-motif structure (DiMS) for signal transduction, coupled with exonuclease III (ExoIII)-assisted DNA walking for signal dual-amplification.

Graphical abstract: LAMP-generated H+ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA

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Publication details

The article was received on 30 Aug 2019, accepted on 18 Sep 2019 and first published on 19 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06738H
Chem. Commun., 2019, Advance Article

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    LAMP-generated H+ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA

    X. Hua, E. Yang, W. Yang, R. Yuan and W. Xu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06738H

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