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Light-activated drug release from prodrug nanoassemblies by structure destruction

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Abstract

We report here a novel light-triggered nanosystem based on co-assembling nanoaggregates (NAs) of lipophilic photosensitizers and lipophilic prodrugs containing multiple thioethers. Upon laser irradiation, the oxidization of the multiple thioethers by photosensitizer-generated singlet oxygen could rapidly destroy the NA structure, resulting in faster drug release than those containing a single thioether.

Graphical abstract: Light-activated drug release from prodrug nanoassemblies by structure destruction

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Publication details

The article was received on 27 Aug 2019, accepted on 01 Oct 2019 and first published on 01 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06673J
Chem. Commun., 2019, Advance Article

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    Light-activated drug release from prodrug nanoassemblies by structure destruction

    Y. Li, S. Wang, Y. Huang, Y. Chen, W. Wu, Y. Liu, J. Zhang, Y. Feng, X. Jiang and M. Gou, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06673J

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