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Issue 91, 2019
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Direct amide synthesis via Ni-mediated aminocarbonylation of arylboronic acids with CO and nitroarenes

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Abstract

Herein we describe an alternative and unconventional approach of an aminocarbonylation reaction to access aryl amides from readily available and low-cost arylboronic acids and nitroarenes. Nickel metal can serve as both reductant and catalyst in this direct aminocarbonylation. This protocol exhibits a good functional group compatibility and allows a variety of aryl amides to be synthesized, including several drug-like molecules.

Graphical abstract: Direct amide synthesis via Ni-mediated aminocarbonylation of arylboronic acids with CO and nitroarenes

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Publication details

The article was received on 26 Aug 2019, accepted on 18 Oct 2019 and first published on 19 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06638A
Chem. Commun., 2019,55, 13709-13712

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    Direct amide synthesis via Ni-mediated aminocarbonylation of arylboronic acids with CO and nitroarenes

    N. Shen, C. W. Cheung and J. Ma, Chem. Commun., 2019, 55, 13709
    DOI: 10.1039/C9CC06638A

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