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Issue 85, 2019
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A pyrophosphate-activated nanochannel inspired by a TRP ion channel

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Abstract

A pyrophosphate (PPi) selectively activated potassium channel was constructed via introducing the isoniazid functionalized calix[4]arene (C4NP) into a biomimetic nanochannel. The activation mechanism is mainly due to the changing of the inner surface charge and wettability of the nanochannel caused by PPi binding.

Graphical abstract: A pyrophosphate-activated nanochannel inspired by a TRP ion channel

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Publication details

The article was received on 25 Aug 2019, accepted on 25 Sep 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06615B
Chem. Commun., 2019,55, 12833-12836

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    A pyrophosphate-activated nanochannel inspired by a TRP ion channel

    F. Zhu, G. Yang, M. K. Dhinakaran, R. Wang, M. Song and H. Li, Chem. Commun., 2019, 55, 12833
    DOI: 10.1039/C9CC06615B

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