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A gold(i)-catalysed three-component reaction via trapping oxonium ylides with allenamides

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Abstract

A gold(I)-catalysed three-component reaction between alcohols (and water), α-aryl-α-diazoesters and allenamides has been developed, affording three-component products, tert-allylic ethers (and alcohols), in moderate to excellent yields with excellent geometric selectivity (E : Z > 20 : 1). In addition, this transformation proceeds smoothly with high functional group tolerance and a broad substrate scope under exceptionally mild reaction conditions. Remarkably, a gram-scale reaction is also successfully performed, and the corresponding three-component product can readily react with easily obtained reagents, furnishing diverse products in satisfactory yields.

Graphical abstract: A gold(i)-catalysed three-component reaction via trapping oxonium ylides with allenamides

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Publication details

The article was received on 24 Aug 2019, accepted on 16 Sep 2019 and first published on 18 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06599G
Chem. Commun., 2019, Advance Article

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    A gold(I)-catalysed three-component reaction via trapping oxonium ylides with allenamides

    G. Liu, S. Yu, W. Hu and H. Qiu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06599G

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