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A polyprodrug-based nanoplatform for cisplatin prodrug delivery and combination cancer therapy

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Abstract

Polyprodrug-based delivery technique is a fast-growing and effective strategy to improve the therapeutic efficacy of small molecule drugs. We herein developed a robust mitoxantrone (MTO)-based polyprodrug nanoplatform for systemic cisplatin prodrug delivery and combination cancer therapy. Our results show that this nanoplatform can concurrently transport MTO and cisplatin to tumor cells and significantly inhibit tumor growth.

Graphical abstract: A polyprodrug-based nanoplatform for cisplatin prodrug delivery and combination cancer therapy

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The article was received on 23 Aug 2019, accepted on 26 Oct 2019 and first published on 28 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06567A
Chem. Commun., 2019, Advance Article

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    A polyprodrug-based nanoplatform for cisplatin prodrug delivery and combination cancer therapy

    C. Lin, Y. Tao, P. E. Saw, M. Cao, H. Huang and X. Xu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06567A

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