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High-resolution solid-state NMR spectroscopy of hydrated non-crystallized RNA

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Abstract

We highlight that sufficient hydration of non-crystallized RNA could provide high-resolution solid-state NMR (SSNMR) spectra, with similar spectral quality to the crystallized RNA. This leads to a greatly simplified RNA preparation approach by ethanol precipitation for high-resolution SSNMR studies. It will greatly broaden the scope of SSNMR applications to the characterization of RNAs.

Graphical abstract: High-resolution solid-state NMR spectroscopy of hydrated non-crystallized RNA

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Publication details

The article was received on 23 Aug 2019, accepted on 26 Oct 2019 and first published on 28 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06552K
Chem. Commun., 2019, Advance Article

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    High-resolution solid-state NMR spectroscopy of hydrated non-crystallized RNA

    S. Zhao, Y. Yang, Y. Zhao, X. Li, Y. Xue and S. Wang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06552K

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