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Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

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Abstract

A visible light-mediated α-functionalization of 1,3-dicarbonyl compounds with switchable selectivity induced by disulfide is disclosed. Upon irradiation with visible light, the metal- and base-free α-hydroxylation or α-hydroxymethylation reaction proceeded smoothly through a disulfide-catalyzed oxidation under mild conditions. The combination of a continuous-flow strategy could further improve the reaction efficiencies.

Graphical abstract: Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

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Publication details

The article was received on 23 Aug 2019, accepted on 07 Oct 2019 and first published on 07 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06544J
Chem. Commun., 2019, Advance Article

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    Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

    J. Zhao, F. Yang, Z. Yu, X. Tang, Y. Wu, C. Ma and Q. Meng, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06544J

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