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Quinoxaline derivatives disrupt the base stacking of hepatitis C virus-internal ribosome entry site RNA: reduce translation and replication

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Abstract

RNA-biased small molecules with a monoquinoxaline core target the L-shaped structure of subdomain IIa of Hepatitis C virus internal ribosome entry site (IRES) RNA in proximity to the Mg2+ binding site. The binding event leads to the destacking of RNA bases, resulting in the inhibition of IRES-mediated translation and HCV RNA replication.

Graphical abstract: Quinoxaline derivatives disrupt the base stacking of hepatitis C virus-internal ribosome entry site RNA: reduce translation and replication

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Publication details

The article was received on 22 Aug 2019, accepted on 14 Oct 2019 and first published on 15 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06531H
Chem. Commun., 2019, Advance Article

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    Quinoxaline derivatives disrupt the base stacking of hepatitis C virus-internal ribosome entry site RNA: reduce translation and replication

    J. Chakraborty, A. Kanungo, T. Mahata, K. Kumar, G. Sharma, R. Pal, K. S. Ahammed, D. Patra, B. Majhi, S. Chakrabarti, S. Das and S. Dutta, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06531H

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