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Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

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Abstract

The introduction of an electron-donating group (e.g., methoxy or piperidinyl) onto the pyrene moiety of 5-(pyrenylethynyl)-2′-deoxyuridine (PyU) increases its DNA-mediated reductive electron-transfer efficiency. In addition, these modifications dramatically inhibit photoinduced guanine oxidation.

Graphical abstract: Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

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Publication details

The article was received on 21 Aug 2019, accepted on 16 Oct 2019 and first published on 23 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06498B
Chem. Commun., 2019, Advance Article

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    Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene

    T. Okuda, Y. Kawashima, Y. Kasahara, T. Takagi, J. Yamamoto, S. Iwai and S. Obika, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06498B

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