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Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells

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Abstract

No methodology has been built to distinguish intracellular SERS nanosensors from cell outer membrane bound-ones. Here we propose a “turning off” strategy by combining etchable SERS nanosensors with a non-permeable etchant. The SERS signals outside the living cells can be rapidly removed, leaving only the internalized nanosensors for imaging and thereby allowing accurate intracellular pH and H2O2 sensing.

Graphical abstract: Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells

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Publication details

The article was received on 21 Aug 2019, accepted on 03 Oct 2019 and first published on 04 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06485K
Chem. Commun., 2019, Advance Article

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    Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells

    L. Bai, X. Wang, K. Zhang, X. Tan, Y. Zhang and W. Xie, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06485K

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