Recent Advance in the Synthesis and Applications of α-(Trifluoromethyl)styrenes in Organic Synthesis
α-trifluoromethylstyrene derivatives are versatile synthetic intermediates for the preparation of more complex fluorinated compounds. Much attention has been recently attracted from the organic chemistry community, because they have been successfully utilized in the transformations of C-F bond activation in a CF3 group, mainly including anionic SN2'-type substitution, cationic SN1'-type substitution, ispo-substitution, defluorinative functionalization with transition metal or photoredox catalysts. In addition, the transition metal-catalyzed cycloaddition reactions of α-trifluoromethylstyrenes have been developed for the construction of cycloalkanes and cycloalkenes containing fluoro or trifluoromethyl groups. In this review, we systematically summarized the synthesis of α-trifluoromethylstyrenes, their applications in organic synthetic chemistry, and their mechanisms were also discussed.