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Palladium-catalyzed decarboxylative ortho-amidation of O-methyl ketoximes with oxamic acids

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Abstract

The first palladium-catalyzed ortho-amidation of ketoximes has been developed with readily available, easy to handle and environment-friendly N,N-disubstituted oxamic acids as the amidation sources. When N-monosubstituted oxamic acids are used as the substrates, the formed ortho-amidated ketoximes undergo further intramolecular cyclization to provide 3-methyleneisoindolinones.

Graphical abstract: Palladium-catalyzed decarboxylative ortho-amidation of O-methyl ketoximes with oxamic acids

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Publication details

The article was received on 20 Aug 2019, accepted on 24 Sep 2019 and first published on 25 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06460E
Chem. Commun., 2019, Advance Article

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    Palladium-catalyzed decarboxylative ortho-amidation of O-methyl ketoximes with oxamic acids

    K. Jing, P. Cui and G. Wang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06460E

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