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Mitochondrial heat shock protein-guided photodynamic therapy

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Abstract

Mitochondria targeting sensitizers are continuing to gain importance in photodynamic therapy (PDT). Members of the 90 kDa heat shock protein (Hsp90) family, including TRAP1 (Hsp75), are overexpressed in cancer cells and help to control the antiapoptotic protein activity. The present work introduces an Hsp90 inhibitor-mitochondria targeting indocyanine dye conjugate (IR-PU) for high PDT efficacy.

Graphical abstract: Mitochondrial heat shock protein-guided photodynamic therapy

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Publication details

The article was received on 19 Aug 2019, accepted on 19 Sep 2019 and first published on 27 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06411G
Chem. Commun., 2019, Advance Article

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    Mitochondrial heat shock protein-guided photodynamic therapy

    A. P. Thomas, A. Lee, L. Palanikumar, B. Jana, K. Kim, S. Kim, H. Ok, J. Seol, D. Kim, B. H. Kang and J. Ryu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06411G

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