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Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

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Abstract

Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal β-glucocerebrosidase or α-mannosidase depending on valency and topology, offering new opportunities in multitargeted drug design.

Graphical abstract: Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

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Publication details

The article was received on 16 Aug 2019, accepted on 01 Oct 2019 and first published on 01 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06376E
Chem. Commun., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

    M. González-Cuesta, D. Goyard, E. Nanba, K. Higaki, J. M. García Fernández, O. Renaudet and C. Ortiz Mellet, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06376E

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