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A ribonuclease-dependent cleavable beacon primer triggering DNA amplification for single nucleotide mutation detection with ultrahigh sensitivity and selectivity

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Abstract

We described a ribonuclease-dependent cleavable beacon primer, an energy-transfer-tagged oligonucleotide inserted with a ribonucleotide, which can be cleaved by ribonuclease to generate enhanced fluorescence signals and initiate DNA amplification for single nucleotide mutation detection with ultrahigh sensitivity and selectivity.

Graphical abstract: A ribonuclease-dependent cleavable beacon primer triggering DNA amplification for single nucleotide mutation detection with ultrahigh sensitivity and selectivity

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Publication details

The article was received on 13 Aug 2019, accepted on 25 Sep 2019 and first published on 25 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06296C
Chem. Commun., 2019, Advance Article

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    A ribonuclease-dependent cleavable beacon primer triggering DNA amplification for single nucleotide mutation detection with ultrahigh sensitivity and selectivity

    X. Ding, K. Yin, J. Chen, K. Wang and C. Liu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06296C

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