Xiong Ding, Kun Yin, Ju Chen, Kepeng Wang and Changchun Liu
Chem. Commun., 2019,55, 12623-12626
DOI:
10.1039/C9CC06296C,
Communication
We described a ribonuclease-dependent cleavable beacon primer, an energy-transfer-tagged oligonucleotide inserted with a ribonucleotide, which can be cleaved by ribonuclease to generate enhanced fluorescence signals and initiate DNA amplification for single nucleotide mutation detection with ultrahigh sensitivity and selectivity.