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Direct monitoring of equilibrium protein folding–unfolding by atomic force microscopy: pushing the limit

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Abstract

We report the direct observation of equilibrium folding–unfolding dynamics of a mechanically labile, three helix bundle protein GA using a commercial atomic force microscope (AFM). Our study extends the capability of commercial AFMs towards studying protein unfolding/refolding at equilibrium as well as increasingly complex biomolecular systems in the context of biological function.

Graphical abstract: Direct monitoring of equilibrium protein folding–unfolding by atomic force microscopy: pushing the limit

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Publication details

The article was received on 13 Aug 2019, accepted on 07 Oct 2019 and first published on 07 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06293A
Chem. Commun., 2019, Advance Article

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    Direct monitoring of equilibrium protein folding–unfolding by atomic force microscopy: pushing the limit

    A. Xiao and H. Li, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06293A

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