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“Off–on” switching of intracellular singlet oxygen release under biocompatible conditions

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Abstract

Precise spatiotemporal control of singlet oxygen generation is of immense importance considering its involvement in photodynamic therapy. In this work, we present a rational design for an endoperoxide which is highly stable at ambient temperatures yet, can rapidly be converted into a highly labile endoperoxide, thus releasing the “stored” singlet oxygen on demand. The “off–on” chemical switching from the stable to the labile form is accomplished by the reaction with fluoride ions. The potential utility of controlled singlet oxygen release was demonstrated in cell cultures.

Graphical abstract: “Off–on” switching of intracellular singlet oxygen release under biocompatible conditions

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Publication details

The article was received on 11 Aug 2019, accepted on 25 Sep 2019 and first published on 15 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06231A
Chem. Commun., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    “Off–on” switching of intracellular singlet oxygen release under biocompatible conditions

    E. Ucar, D. Xi, O. Seven, C. Kaya, X. Peng, W. Sun and E. U. Akkaya, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06231A

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