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An ultrasensitive electrochemiluminescence biosensor for nuclear factor kappa B p50 based on the proximity hybridization-induced hybridization chain reaction

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Abstract

Nuclear factor kappa B p50 (NF-κB p50) induces various biological processes. In this study, a highly selective and sensitive electrochemiluminescence (ECL) biosensor for the detection of NF-κB p50 has been developed, which combines the high selectivity of the proximity hybridization assay (PHA) with the high efficiency of the hybridization chain reaction (HCR).

Graphical abstract: An ultrasensitive electrochemiluminescence biosensor for nuclear factor kappa B p50 based on the proximity hybridization-induced hybridization chain reaction

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Publication details

The article was received on 11 Aug 2019, accepted on 02 Oct 2019 and first published on 10 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06210F
Chem. Commun., 2019, Advance Article

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    An ultrasensitive electrochemiluminescence biosensor for nuclear factor kappa B p50 based on the proximity hybridization-induced hybridization chain reaction

    X. Huang, Y. Zhang, W. Xu, W. Xu, L. Guo, B. Qiu and Z. Lin, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06210F

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