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Issue 81, 2019
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Rh(iii)-catalyzed alkynylation: synthesis of functionalized quinolines from aminohydrazones

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Abstract

Rhodium-catalyzed, chemo- and regioselective synthesis of functionalized quinolines using 2-aminohydrazones and terminal alkynes has been described. The reaction is oxidant/base-free and tolerates a wide variety of functional groups and has been successfully extended with 1,3 and 1,4-bis(phenylethynyl)benzenes to afford 1,3- and 1,4-bis(4-methylquinolin-2-yl)benzenes and 2-(3/4-ethynylphenyl)-4-methylquinolines. Furthermore, the control experiment supports the proposed reaction mechanism.

Graphical abstract: Rh(iii)-catalyzed alkynylation: synthesis of functionalized quinolines from aminohydrazones

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Article information


Submitted
10 Aug 2019
Accepted
13 Sep 2019
First published
13 Sep 2019

Chem. Commun., 2019,55, 12168-12171
Article type
Communication

Rh(III)-catalyzed alkynylation: synthesis of functionalized quinolines from aminohydrazones

P. Kumar, V. Garg, M. Kumar and A. K. Verma, Chem. Commun., 2019, 55, 12168
DOI: 10.1039/C9CC06205J

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