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Issue 98, 2019
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An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

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Abstract

A self-delivery system consisting of lonidamine and a self-assembling peptide was designed for the selective killing of phosphatase-overexpressing cancer cells, which was mediated by both enhanced cellular uptake of LND–peptide and enzyme-triggered intracellular fiber formation, thereby providing a generalized strategy to develop cancer-targeting systems of drug conjugates.

Graphical abstract: An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

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Publication details

The article was received on 10 Aug 2019, accepted on 19 Nov 2019 and first published on 19 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC06204A
Chem. Commun., 2019,55, 14852-14855

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    An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

    C. Wu, J. Liu, X. Tang, Z. Zhai, K. Xu and W. Zhong, Chem. Commun., 2019, 55, 14852
    DOI: 10.1039/C9CC06204A

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