Can Wu, Jing Liu, Xuan Tang, Ziran Zhai, Keming Xu and Wenying Zhong
Chem. Commun., 2019,55, 14852-14855
DOI:
10.1039/C9CC06204A,
Communication
A self-delivery system consisting of lonidamine and a self-assembling peptide was designed for the selective killing of phosphatase-overexpressing cancer cells, which was mediated by both enhanced cellular uptake of LND–peptide and enzyme-triggered intracellular fiber formation, thereby providing a generalized strategy to develop cancer-targeting systems of drug conjugates.