An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

Can Wu; Jing Liu; Xuan Tang; Ziran Zhai; Keming Xu; Wenying Zhong

doi:10.1039/C9CC06204A

An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells†

Can Wu,^a Jing Liu,^a Xuan Tang,^a Ziran Zhai,^a Keming Xu

*^a and Wenying Zhong

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China
E-mail: wyzhong@cpu.edu.cn, xus1019@163.com

^b Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, China

Abstract

A self-delivery system consisting of lonidamine and a self-assembling peptide was designed for the selective killing of phosphatase-overexpressing cancer cells, which was mediated by both enhanced cellular uptake of LND–peptide and enzyme-triggered intracellular fiber formation, thereby providing a generalized strategy to develop cancer-targeting systems of drug conjugates.

Supplementary files

Publication details

The article was received on 10 Aug 2019, accepted on 19 Nov 2019 and first published on 19 Nov 2019

Article type: Communication

DOI: 10.1039/C9CC06204A

Citation: Chem. Commun., 2019,55, 14852-14855

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An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

C. Wu, J. Liu, X. Tang, Z. Zhai, K. Xu and W. Zhong, Chem. Commun., 2019, 55, 14852
DOI: 10.1039/C9CC06204A
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Chemical Communications

An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells†

Abstract

Supplementary files

Publication details

An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

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