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Abstract | Cited by

A self-delivery system consisting of lonidamine and a self-assembling peptide was designed for the selective killing of phosphatase-overexpressing cancer cells, which was mediated by both enhanced cellular uptake of LND–peptide and enzyme-triggered intracellular fiber formation, thereby providing a generalized strategy to develop cancer-targeting systems of drug conjugates.

Graphical abstract: An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

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