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A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy

Abstract

Cancer cells adapt to cellular oxidative stress by increasing glutathione (GSH). An organically modified silica nanosystem (ORMOSIL@GOx) was fabricated to achieve a lethal level of oxidative stress in cancer cells by depleting intracellular GSH while increasing reactive oxygen species.

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Publication details

The article was received on 03 Aug 2019, accepted on 11 Oct 2019 and first published on 11 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06043J
Chem. Commun., 2019, Accepted Manuscript

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    A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy

    W. K. Ong, D. Jana and Y. Zhao, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC06043J

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