A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion†
Abstract
A bimetallic complex, containing Mn(II) and Cu(II) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (˙OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.