Issue 83, 2019
From the journal:

Chemical Communications

A mitochondria-targeting dinuclear Ir–Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells†

Cheng Zhang,a   Ruilin Guan,a   Xinxing Liao,a   Cheng Ouyang,a   Thomas W. Rees,a   Jiangping Liu,a   Yu Chen, ORCID logo *a   Liangnian Jia  and  Hui Chao ORCID logo *ab  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, P. R. China
E-mail: ceschh@mail.sysu.edu.cn, chenyu63@mail.sysu.edu.cn

b College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, P. R. China

Abstract

A mitochondria-targeting hetero-binuclear Ir(III)–Ru(II) complex was developed as a photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) bifunctional agent to achieve a synergistic effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells.

Graphical abstract: A mitochondria-targeting dinuclear Ir–Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

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Article information

DOI
https://doi.org/10.1039/C9CC05998A
Article type
Communication
Submitted
01 Aug 2019
Accepted
23 Sep 2019
First published
23 Sep 2019

Chem. Commun., 2019,55, 12547-12550

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A mitochondria-targeting dinuclear Ir–Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

C. Zhang, R. Guan, X. Liao, C. Ouyang, T. W. Rees, J. Liu, Y. Chen, L. Ji and H. Chao, Chem. Commun., 2019, 55, 12547 DOI: 10.1039/C9CC05998A

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