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Issue 83, 2019
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A mitochondria-targeting dinuclear Ir–Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

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Abstract

A mitochondria-targeting hetero-binuclear Ir(III)–Ru(II) complex was developed as a photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) bifunctional agent to achieve a synergistic effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells.

Graphical abstract: A mitochondria-targeting dinuclear Ir–Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

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Publication details

The article was received on 01 Aug 2019, accepted on 23 Sep 2019 and first published on 23 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC05998A
Chem. Commun., 2019,55, 12547-12550

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    A mitochondria-targeting dinuclear Ir–Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

    C. Zhang, R. Guan, X. Liao, C. Ouyang, T. W. Rees, J. Liu, Y. Chen, L. Ji and H. Chao, Chem. Commun., 2019, 55, 12547
    DOI: 10.1039/C9CC05998A

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