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Mn(I)-Catalyzed Nucleophilic Addition/Ring Expansion via C-H Activation and C-C Cleavage

Abstract

Mn(I)-catalyzed synthesis of Seven- or eight-membered carbocycles is disclosed via C-H activation of heteroarenes and coupling with alkyne-functionalized 1,3-cyclopentadiones or 1,3-cyclohexadiones. This n to n+2 (n = 5, 6) ring expansion reaction proceeded via a C-H alkenylation/carbonyl addition/retro-Aldol cascade. Structurally diverse mid-sized carbocycles were constructed via cleavage of both C-H and C-C bonds in a single operation.

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Publication details

The article was received on 01 Aug 2019, accepted on 15 Aug 2019 and first published on 15 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05973C
Chem. Commun., 2019, Accepted Manuscript

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    Mn(I)-Catalyzed Nucleophilic Addition/Ring Expansion via C-H Activation and C-C Cleavage

    B. Liu, Y. Yuan, P. Hu, G. zheng, D. Bai, J. Chang and X. Li, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC05973C

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