Jump to main content
Jump to site search


An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease

Author affiliations

Abstract

Cell penetrating peptide (CPP), LK-3, causes a ca. 10-fold increase in the cell penetration of cyclosporin A (CsA) at nanomolar concentrations. The results of an in vivo dry eye mouse model demonstrated that a 100-fold lower dose of the CsA/LK-3 complex than that of Restasis® is sufficient to cause the same therapeutic effect.

Graphical abstract: An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Aug 2019, accepted on 28 Sep 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC05960A
Chem. Commun., 2019, Advance Article

  •   Request permissions

    An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease

    S. Hyun, L. Li, K. C. Yoon and J. Yu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05960A

Search articles by author

Spotlight

Advertisements