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Pd-Catalyzed regioselective synthesis of 2,6-disubstituted pyridines through denitrogenation of pyridotriazoles and 3,8-diarylation of imidazo[1,2-a]pyridines

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Abstract

Synthesis of 2,6-disubstituted pyridines from pyridotriazoles through palladium-catalyzed aerobic oxidative denitrogenative reactions has been described. Denitrogenation of arylated pyridotriazoles generates metal-carbene intermediates in situ and provides selectively 6-aryl-2-benzoylpyridines. The same conditions have been extended to regioselective C-3 and C-8 diarylation of several imidazo[1,2-a]pyridines.

Graphical abstract: Pd-Catalyzed regioselective synthesis of 2,6-disubstituted pyridines through denitrogenation of pyridotriazoles and 3,8-diarylation of imidazo[1,2-a]pyridines

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Publication details

The article was received on 31 Jul 2019, accepted on 15 Aug 2019 and first published on 15 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05953A
Chem. Commun., 2019, Advance Article

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    Pd-Catalyzed regioselective synthesis of 2,6-disubstituted pyridines through denitrogenation of pyridotriazoles and 3,8-diarylation of imidazo[1,2-a]pyridines

    A. Joshi, R. Semwal, E. Suresh and S. Adimurthy, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05953A

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