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Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy

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Abstract

Bifunctional supramolecular prodrug vesicles have been successfully constructed based on the complexation between a glutathione (GSH)-responsive prodrug guest molecule (DNS-CPT) and a water-soluble pillar[5]arene (WP5) for cancer diagnosis and therapy. Under the microenvironment of cancer cells with high GSH concentration, 7-ethyl-10-hydroxycamptothecin (SN-38) with strong yellow fluorescence can be efficiently released from the prodrug DNS-CPT for drug location and cancer therapy.

Graphical abstract: Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy

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Publication details

The article was received on 28 Jul 2019, accepted on 14 Aug 2019 and first published on 15 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05859A
Chem. Commun., 2019, Advance Article

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    Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy

    G. Sun, Z. He, M. Hao, Z. Xu, X. Hu, J. Zhu and L. Wang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05859A

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