Jump to main content
Jump to site search


Construction of Benzofuranone Library via Metal-Free, One-Pot Intermolecular Condensation and Their Application as Efficient Estrogen Receptor β Modulators

Abstract

Facile synthesis of benzofuranone was achieved through a metal-free, one-pot, intermolecular condensation between -hydroxy aryl ketones and resorcinol derivatives. A library of 20 compounds was prepared with moderate to good overall yields. These compounds showed strong binding toward estrogen receptors along with good selectivity for ERβ (>190-fold over ERα). Anti-proliferative activity on DU-145, U-87, and MCF-7 cells gave inhibition IC50 in the low uM range, which suggested the promising potential therapeutic applications of these new class of benzofuranones.

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Jul 2019, accepted on 02 Oct 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC05756K
Chem. Commun., 2019, Accepted Manuscript

  •   Request permissions

    Construction of Benzofuranone Library via Metal-Free, One-Pot Intermolecular Condensation and Their Application as Efficient Estrogen Receptor β Modulators

    X. Peng, Z. Hu, J. Zhang, W. Ning, S. Zhang, C. Dong, X. Shi and H. Zhou, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC05756K

Search articles by author

Spotlight

Advertisements