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Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

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Abstract

The syntheses of substituted all-cis-1,2,3-trifluorocyclopropanes are described for the first time. The three fluorines located on each of the cyclopropyl carbons with a stereochemistry where they are all on the same face of the cyclopropane, imparts a significant polarity to the molecule, and the inherent conformational rigidity and lowering of log P makes this motif attractive for exploration as a substituent for pharmaceuticals and agrochemicals research.

Graphical abstract: Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

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Publication details

The article was received on 24 Jul 2019, accepted on 09 Aug 2019 and first published on 09 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05749H
Chem. Commun., 2019, Advance Article

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    Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

    Z. Fang, D. B. Cordes, A. M. Z. Slawin and D. O'Hagan, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05749H

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