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C–H alkenylation/cyclization and sulfamidation of 2-phenylisatogens using N-oxide as a directing group

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Abstract

The first example of transition-metal-catalyzed C–H activations of 2-phenylisatogens with alkynes and sulfonyl azides has been developed using N-oxide as the directing group. Ru(II)-Catalyzed C–H alkenylation/cyclization and Ir(III)-catalyzed direct C–H sulfamidation proceeded with good yields and excellent functional group tolerance. Importantly, these two transformations provided straightforward routes for the synthesis of indol-3-one derivatives and sulfamidated 2-phenylisatogens respectively, which might be of considerable bioactivities.

Graphical abstract: C–H alkenylation/cyclization and sulfamidation of 2-phenylisatogens using N-oxide as a directing group

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Publication details

The article was received on 23 Jul 2019, accepted on 12 Aug 2019 and first published on 13 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05719F
Chem. Commun., 2019, Advance Article

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    C–H alkenylation/cyclization and sulfamidation of 2-phenylisatogens using N-oxide as a directing group

    L. Guo, B. Tang, R. Nie, Y. Liu, S. Lv, H. Wang, L. Guo, L. Hai and Y. Wu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05719F

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