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Issue 83, 2019
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Neutralization of insulin by photocleavage under high vacuum

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Abstract

Charge reduction and neutralization of electro-sprayed peptides are realized by selective gas-phase photocleavage of tailored covalent tags. The concept is demonstrated with four model peptides in positive and negative ion modes and tagged insulin as the largest construct.

Graphical abstract: Neutralization of insulin by photocleavage under high vacuum

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Supplementary files

Article information


Submitted
23 Jul 2019
Accepted
25 Sep 2019
First published
25 Sep 2019

This article is Open Access

Chem. Commun., 2019,55, 12507-12510
Article type
Communication

Neutralization of insulin by photocleavage under high vacuum

J. Schätti, M. Kriegleder, M. Debiossac, M. Kerschbaum, P. Geyer, M. Mayor, M. Arndt and V. Köhler, Chem. Commun., 2019, 55, 12507
DOI: 10.1039/C9CC05712A

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