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Issue 83, 2019
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Neutralization of insulin by photocleavage under high vacuum

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Abstract

Charge reduction and neutralization of electro-sprayed peptides are realized by selective gas-phase photocleavage of tailored covalent tags. The concept is demonstrated with four model peptides in positive and negative ion modes and tagged insulin as the largest construct.

Graphical abstract: Neutralization of insulin by photocleavage under high vacuum

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Publication details

The article was received on 23 Jul 2019, accepted on 25 Sep 2019 and first published on 25 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC05712A
Chem. Commun., 2019,55, 12507-12510
  • Open access: Creative Commons BY-NC license
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    Neutralization of insulin by photocleavage under high vacuum

    J. Schätti, M. Kriegleder, M. Debiossac, M. Kerschbaum, P. Geyer, M. Mayor, M. Arndt and V. Köhler, Chem. Commun., 2019, 55, 12507
    DOI: 10.1039/C9CC05712A

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