Issue 83, 2019

Neutralization of insulin by photocleavage under high vacuum

Abstract

Charge reduction and neutralization of electro-sprayed peptides are realized by selective gas-phase photocleavage of tailored covalent tags. The concept is demonstrated with four model peptides in positive and negative ion modes and tagged insulin as the largest construct.

Graphical abstract: Neutralization of insulin by photocleavage under high vacuum

Supplementary files

Article information

Article type
Communication
Submitted
23 Jul 2019
Accepted
25 Sep 2019
First published
25 Sep 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 12507-12510

Neutralization of insulin by photocleavage under high vacuum

J. Schätti, M. Kriegleder, M. Debiossac, M. Kerschbaum, P. Geyer, M. Mayor, M. Arndt and V. Köhler, Chem. Commun., 2019, 55, 12507 DOI: 10.1039/C9CC05712A

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