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Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy

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Abstract

Cholesterol (CHOL) is an indispensable component of liposomes. Incorporation of 7-dehydrocholesterol (7-DHC) instead of CHOL can efficiently enhance the anticancer activity of photosensitizer-encapsulated liposomes upon irradiation, yielding an IC50 value about half of that of CHOL-based controls. The photo-oxidation of 7-DHC into its endoperoxide form by singlet oxygen may account for the enhanced therapeutic effect, realizing an efficient combination of photodynamic therapy (PDT) and photoactivated chemotherapy.

Graphical abstract: Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy

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Publication details

The article was received on 23 Jul 2019, accepted on 01 Nov 2019 and first published on 07 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC05691B
Chem. Commun., 2019, Advance Article

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    Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy

    Y. Wang, N. Tian, C. Li, Y. Hou, X. Wang and Q. Zhou, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05691B

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