Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy

Youchao Wang; Nana Tian; Chao Li; Yuanjun Hou; Xuesong Wang; Qianxiong Zhou

doi:10.1039/C9CC05691B

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Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy†

Youchao Wang,^ab Nana Tian,^ab Chao Li,^a Yuanjun Hou,^a Xuesong Wang

*^ab and Qianxiong Zhou

*^a

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* Corresponding authors

^a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: xswang@mail.ipc.ac.cn, zhouqianxiong@mail.ipc.ac.cn
Fax: +86-10-62564049
Tel: +86-10-82543592

^b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

Cholesterol (CHOL) is an indispensable component of liposomes. Incorporation of 7-dehydrocholesterol (7-DHC) instead of CHOL can efficiently enhance the anticancer activity of photosensitizer-encapsulated liposomes upon irradiation, yielding an IC₅₀ value about half of that of CHOL-based controls. The photo-oxidation of 7-DHC into its endoperoxide form by singlet oxygen may account for the enhanced therapeutic effect, realizing an efficient combination of photodynamic therapy (PDT) and photoactivated chemotherapy.

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Article information

DOI: https://doi.org/10.1039/C9CC05691B
Article type: Communication
Submitted: 23 Jul 2019
Accepted: 01 Nov 2019
First published: 07 Nov 2019

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Chem. Commun., 2019,55, 14081-14084

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Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy

Y. Wang, N. Tian, C. Li, Y. Hou, X. Wang and Q. Zhou, Chem. Commun., 2019, 55, 14081 DOI: 10.1039/C9CC05691B

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Chemical Communications

Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy†

Abstract

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Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy

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