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Issue 73, 2019
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Effect of solvent polarity in mechanochemistry: preparation of a conglomerate vs. racemate

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Abstract

Cocrystallization of racemic DL-tartaric acid (DL-ta) and achiral isoniazid (ISN) was investigated using mechanochemistry. Neat grinding (NG) and liquid-assisted grinding (LAG) in the presence of non-polar liquids result in the formation of a conglomerate (ISN·D-ta/ISN·L-ta); whereas LAG with polar liquids yields racemic salt ISN·DL-ta. The effect of solvent polarity and dipole moment in mechanochemistry is discussed.

Graphical abstract: Effect of solvent polarity in mechanochemistry: preparation of a conglomerate vs. racemate

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Article information


Submitted
23 Jul 2019
Accepted
13 Aug 2019
First published
19 Aug 2019

Chem. Commun., 2019,55, 10900-10903
Article type
Communication

Effect of solvent polarity in mechanochemistry: preparation of a conglomerate vs. racemate

K. K. Sarmah, T. Rajbongshi, A. Bhuyan and R. Thakuria, Chem. Commun., 2019, 55, 10900
DOI: 10.1039/C9CC05687D

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