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Stepwise dual stimuli triggered dual drug release by a single naphthalene based two-photon chromophore to reverse MDR for alkylating agents with dual surveillance in uncaging steps

Abstract

In this work, we depleted Glutathione (GSH) by releasing SO2 with internal stimulus GSH itself, and also selectively marked the cancer cell followed by release of anticancer drug using other orthogonal stimulus i.e. two-photon (TP) NIR light by a single naphthalene based chromophore (TP absorbance 77 GM and uncaging cross-section 21 GM). We demonstrated the improved therapeutic efficacy of chlorambucil by orthogonal stimulus approach and dual surveillance of both drug uncaging process in real-time using in vitro studies

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Supplementary files

Publication details

The article was received on 20 Jul 2019, accepted on 07 Oct 2019 and first published on 07 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC05604A
Chem. Commun., 2019, Accepted Manuscript

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    Stepwise dual stimuli triggered dual drug release by a single naphthalene based two-photon chromophore to reverse MDR for alkylating agents with dual surveillance in uncaging steps

    B. Roy, M. Kundu, A. K. Singh, T. Singha, S. Bhattacharya, P. K. Datta, M. Mandal and S. N. D. Pradeep, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC05604A

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