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High-throughput and ultra-sensitive single-cell profiling of multiple microRNAs and identification of human cancer

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Abstract

We established an efficient method for single-cell miRNA analysis by droplet microfluidics, which has high sensitivity of single molecule detection and high throughput. Single-cell analysis of multiple miRNAs in various cells shows that miRNA expression is closely related to cancer type. CTC analysis shows that the method is applicable for rare cell analysis.

Graphical abstract: High-throughput and ultra-sensitive single-cell profiling of multiple microRNAs and identification of human cancer

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Publication details

The article was received on 18 Jul 2019, accepted on 02 Aug 2019 and first published on 03 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05553C
Chem. Commun., 2019, Advance Article

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    High-throughput and ultra-sensitive single-cell profiling of multiple microRNAs and identification of human cancer

    L. Li, M. Lu, Y. Fan, L. Shui, S. Xie, R. Sheng, H. Si, Q. Li, Y. Wang and B. Tang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05553C

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