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Issue 84, 2019
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Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

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Abstract

Polyubiquitination with diverse linkages on histones provides another layer of accuracy and complexity for epigenetic regulation, which is rarely studied. Herein, K27 or K48-diubiquitin modified H2A analogues were chemically synthesized using thiirane linkers. These permitted in vitro binding studies suggested the plasticity of ubiquitin chains in 53BP1 recognition.

Graphical abstract: Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

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Publication details

The article was received on 17 Jul 2019, accepted on 18 Sep 2019 and first published on 24 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC05526F
Chem. Commun., 2019,55, 12639-12642

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    Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

    J. Liang, Q. Gong, Y. Li, Y. Zheng, J. Zheng, C. Tian and J. Li, Chem. Commun., 2019, 55, 12639
    DOI: 10.1039/C9CC05526F

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