Jump to main content
Jump to site search

Issue 84, 2019
Previous Article Next Article

Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

Author affiliations

Abstract

Polyubiquitination with diverse linkages on histones provides another layer of accuracy and complexity for epigenetic regulation, which is rarely studied. Herein, K27 or K48-diubiquitin modified H2A analogues were chemically synthesized using thiirane linkers. These permitted in vitro binding studies suggested the plasticity of ubiquitin chains in 53BP1 recognition.

Graphical abstract: Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

Back to tab navigation

Supplementary files

Article information


Submitted
17 Jul 2019
Accepted
18 Sep 2019
First published
24 Sep 2019

Chem. Commun., 2019,55, 12639-12642
Article type
Communication

Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

J. Liang, Q. Gong, Y. Li, Y. Zheng, J. Zheng, C. Tian and J. Li, Chem. Commun., 2019, 55, 12639
DOI: 10.1039/C9CC05526F

Social activity

Search articles by author

Spotlight

Advertisements