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Issue 70, 2019
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Enzymatic kinetic resolution of chiral sulfoxides – an enantiocomplementary approach

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Abstract

A new enzymatic assay for the preparation of chiral sulfoxides that is enantiocomplementary to the known (S)-enantiomer-reducing activity of methionine sulfoxide reductase A (MsrA) is described. To this end, we have utilized the enzyme DMSO reductase (DmsABC), recently discovered by us being highly upregulated in stationary phase E. coli bacteria.

Graphical abstract: Enzymatic kinetic resolution of chiral sulfoxides – an enantiocomplementary approach

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Publication details

The article was received on 16 Jul 2019, accepted on 08 Aug 2019 and first published on 08 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05470G
Chem. Commun., 2019,55, 10480-10483

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    Enzymatic kinetic resolution of chiral sulfoxides – an enantiocomplementary approach

    V. Nosek and J. Míšek, Chem. Commun., 2019, 55, 10480
    DOI: 10.1039/C9CC05470G

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