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Issue 92, 2019
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A dithiocarbamate-based H2O2-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy

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Abstract

Here, we report the rational design of a H2O2-responsive diethyldithiocarbamate (DTC)-based prodrug, which chelated Cu(II) to form Cu(DTC)2 with a high anticancer activity in a tumor-microenvironment and induced oxidative stress amplification, showing superior antitumor toxicity to disulfiram.

Graphical abstract: A dithiocarbamate-based H2O2-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy

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Publication details

The article was received on 15 Jul 2019, accepted on 25 Oct 2019 and first published on 25 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC05438C
Chem. Commun., 2019,55, 13896-13899

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    A dithiocarbamate-based H2O2-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy

    Q. Pan, B. Zhang, X. Peng, S. Wan, K. Luo, W. Gao, Y. Pu and B. He, Chem. Commun., 2019, 55, 13896
    DOI: 10.1039/C9CC05438C

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