Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

Sophie Lau; Naomi Stanhope; John Griffin; Eleri Hughes; David A. Middleton

doi:10.1039/C9CC05344A

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Drug orientations within statin-loaded lipoprotein nanoparticles by ¹⁹F solid-state NMR†

Sophie Lau,^a Naomi Stanhope,^a John Griffin,

^a Eleri Hughes^a and David A. Middleton

*^a

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* Corresponding authors

^a Department of Chemistry, Lancaster University, Lancaster LA1 4YB, UK
E-mail: d.middleton@lancaster.ac.uk

Abstract

NMR measurements of ¹⁹F chemical shift anisotropy and ¹H–¹⁹F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.

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Article information

DOI: https://doi.org/10.1039/C9CC05344A
Article type: Communication
Submitted: 11 Jul 2019
Accepted: 14 Oct 2019
First published: 14 Oct 2019
This article is Open Access

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Chem. Commun., 2019,55, 13287-13290

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Drug orientations within statin-loaded lipoprotein nanoparticles by ¹⁹F solid-state NMR

S. Lau, N. Stanhope, J. Griffin, E. Hughes and D. A. Middleton, Chem. Commun., 2019, 55, 13287 DOI: 10.1039/C9CC05344A

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