The Pd-catalyzed C–H alkylation of ortho-methyl-substituted aromatic amides with maleimide occurs preferentially at the ortho-methyl C–H bond over the ortho-C–H bond†
Abstract
The reaction of ortho-methyl-substituted aromatic amides with maleimides in the presence of Pd(OAc)2 and AgOAc results in C–H alkylation at the ortho-methyl C–H bond. DFT calculations indicate that the formation of a five-membered palladacycle is a kinetically favorable step, but the insertion of the maleimide into the six-membered palladacycle is energetically favored.