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Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity

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Abstract

A novel type of hydrogen peroxide (H2O2)-activated diazeniumdiolate based on an α-ketoamide moietey was developed as a nitric oxide (NO) donor. KA-NO-4 inhibited lung cancer cells with submicromolar activity. The H2O2-responsive behaviour of KA-NO-4 was thoroughly investigated. The NO-centered mechanism of action of KA-NO-4 was intracellularly studied.

Graphical abstract: Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity

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Publication details

The article was received on 09 Jul 2019, accepted on 30 Sep 2019 and first published on 30 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC05266F
Chem. Commun., 2019, Advance Article

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    Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity

    J. Fu, J. Han, T. Meng, J. Hu and J. Yin, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05266F

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