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Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic C. elegans

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Abstract

Hydrogen sulfide, an endogenous signalling molecule, is central to several pathophysiological processes in mammalian systems. It scavenges reactive oxygen species and is known to ameliorate dopaminergic neuronal degeneration in neurotoxin-induced Parkinson's disease models. The rapid volatilization of H2S from spontaneously releasing sulfide salts being a challenge, we describe peptide conjugates which exhibit tris(2-carboxyethyl)phosphine mediated “slow and sustained” H2S release. These conjugates reduced hydrogen peroxide-induced oxidative stress and significantly increased dopamine levels in transgenic C. elegans.

Graphical abstract: Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic C. elegans

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Publication details

The article was received on 05 Jul 2019, accepted on 31 Jul 2019 and first published on 31 Jul 2019


Article type: Communication
DOI: 10.1039/C9CC05153H
Chem. Commun., 2019, Advance Article

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    Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic C. elegans

    R. Ali, H. A. Pal, R. Hameed, A. Nazir and S. Verma, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05153H

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